Prerequisites: High school algebra or the instructor's permission. Recommended Preparation: high school physics and chemistry.

Not for credit toward the bachelor's degree. Given on a Pass/Fail basis only. This course is preparation for Chemistry W1403 or the equivalent, as well as for other science courses. It is intended for students who have not attended school for sometime or who do not have a firm grasp of high school chemistry. Topics include atomic and nuclear structure, nomenclature, chemical bonding and its relation to molecular structure, chemical reactions, stoichiometry, periodic properties of elements, equilibria, gas laws, acids and bases, and kinetics.Recitation Section Required.

Prerequisites: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Preparation equivalent to one year of high school chemistry is assumed and concurrent registration in Calculus I. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM W0001 before taking C1403. Topics include stoichiometry, states of matter, chemical equilibria, acids and bases, chemical thermodynamics, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures, chemical kinetics, coordination chemistry, and electrochemistry. Although C1403 and C1404 are separate courses, students are expected to take both terms sequentially. the order of presentation of topics may differ from the order presented here, and from year to year.Recitation Section Required.

Prerequisites: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Topics include kinetic theory of gases, solutions, equilibria, oxidation-reduction, reactions, thermodynamics, chemical kinetics, the electronic structure of atoms, chemical bonding and its relationship to the geometries of molecules, periodic properties of the elements, transition metal complexes, and an introduction to organic chemistry and biochemistry.Recitation Section Required.

Corequisites: CHEM C1403 or W1403.

Laboratory Fee: $140. An introduction to basic techniques of modern experimental chemistry, including quantitative procedures and chemical analysis.

Prerequisites: A grade of "B" or better in CHEM C1403 or W1403 or acceptable performance on the Department placement exam.
Corequisites: Calculus II.

Topics include: Gases (Kinetic Theory of Gases); Binary Collision Model for Chemical Reactions; Chemical Kinetics; Acid-base Equilibria; Thermochemistry (Thermodynamics I); Thermodynamics II Spontaneous Processes; Chemical Bonding in Polyatomic Molecules. Recitation Section Required.

Prerequisites: CHEM C1604 or C3045.

Laboratory Fee: $140. An introduction to basic techniques and practices of modern experimental chemistry, including qualitative procedures and chemical analysis. This course differs from CHEM W1500 in its emphasis on instrumentation and methods.

Prerequisites: A grade of 5 on the Chemistry Advanced Placement exam and an acceptable grade on the Department placement exam.

Not open to students who have taken other courses in college-level chemistry. Premedical students may take CHEM C3045, C3046, and C3545 to meet the minimum requirements for admission to medical school. This course covers the same material as CHEM C3443-C3444, but is intended for students who have learned the principles of general chemistry in high school. The level of instruction is appropriate for those who have not had a college course in general chemistry. Students enrolled in CHEM C3045-C3046 are expected to enroll concurrently in CHEM W2507.Recitation Section Required.

Prerequisites: CHEM C1403 and C1404, or C1604, or C3045 and C3046; PHYS V1201-V1202 is acceptable, PHYS C1401-C1402 is recommended, or the equivalent; and MATH V1101-V1102 or V1207-V1208. Recommended corequisite: CHEM C3085-C3086.

Elementary but comprehensive treatment of the fundamental laws governing the behavior of individual atoms and molecules and collections of them. C3079: The thermodynamics of chemical systems at equilibrium and the chemical kinetics of nonequilibrium systems. C3080: The quantum mechanics of atoms and molecules, the quantum statistical mechanics of chemical systems, and the connection of statistical mechanics to thermodynamics. Recitation Section Required.

Prerequisites: CHEM C3085 is prerequisite for C3086.
Corequisites: CHEM C3079 for CHEM C3085 and C3080 for C3080.

Laboratory Fee: $125 per term. Techniques of experimental physical chemistry and instrumental analysis, including infrared and ultraviolet spectrophotometry, magnetic resonance, electroanalytical methods, calorimetry, reaction kinetics, hydrodynamic methods, and applications of digital computers to the analysis of experimental data.

Prerequisites: CHEM C1404 or W1404 or C1604, and W1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination.Recitation Section Required.

Prerequisites: CHEM C1404 or W1404 or C1604, and W1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Recitation Section Required.

Prerequisites: ENVB W2001 or BIOL C2005 and one year of organic chemistry.

Lecture and recitation. Students wishing to cover the full range of modern biochemistry should take both BIOC C3501 and C3512. Protein structure, protein folding, enzyme kinetics, allostery, membrane transport, biological membranes, and protein targeting. Chemistry and metabolism of amino acids, carbohydrates, lipids, purines, and pyrimidines.

Recitation Section Required.

Prerequisites: CHEM W1500
Corequisites: CHEM C3443 or W3443.

Laboratory Fee: $125. Students planning to take a full year of laboratory should enroll in CHEM W3543 and W3546. Techniques of experimental organic chemistry, with emphasis on understanding fundamental principles underlying the experiments in methodology of solving laboratory problems involving organic molecules.

Prerequisites: CHEM C3045 and C3046 and W2507.

Laboratory Fee: $125. The course covers the same material as CHEM W3543, but is intended for those students who have taken Intensive Organic Chemistry for First-Year Students, CHEM C3045-C3046 and for students who are intending to major in Chemistry, Biochemistry, Chemical Physics or Environmental Chemistry.

Prerequisites: Elementary organic chemistry. (Some background in inorganic and physical chemistry is helpful but not required.)

Main group and transition metal organometallic chemistry: bonding, structure, reactions, kinetics, and mechanisms.

Prerequisites: Elementary organic and physical chemistry.

The mechanisms of organic reactions, structure of organic molecules, and theories of reactivity. How reactive intermediates are recognized and mechanisms are deduced using kinetics, stereochemistry, isotopes, and physical measurements.

Construction, analysis and strategies for the synthesis of complex natutal products.

Prerequisites: Sophomore Organic and Inorganic Chemistry

This course will have two main themes. One theme will explore the design, synthesis, and properties of materials made from molecules. Topics that will be covered in this section of the course include the chemistry of liquid crystals, self-assembled monolayers, organic electronics, carbon-based nanostructures, self-assembled materials, and bio-inspired materials. A second theme will explore inorganic materials. It will compare the chemistry of chemical vapor deposition and vapor phase epitaxy to make solid state materials. It will further study the transformation from chemical bonds to solid-state band structure in materials and quantum size effects.

Prerequisites: Elementary physical chemistry.

Basic quantum mechanics: the Schrodinger equation and its interpretation, exact solutions in simple cases, methods or approximation, angular Mementum and electronic spin, and an introduction to atomic and molecular structure.

Prerequisites: Elementary physical chemistry.
Corequisites: CHEM G4221

Topics include the classical and quantum statistical mechanics of gases, liquids, and solids.

Prerequisites: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Preparation equivalent to one year of high school chemistry is assumed and concurrent registration in Calculus I. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM W0001 before taking C1403. Topics include stoichiometry, states of matter, chemical equilibria, acids and bases, chemical thermodynamics, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures, chemical kinetics, coordination chemistry, and electrochemistry. Although C1403 and C1404 are separate courses, students are expected to take both terms sequentially. the order of presentation of topics may differ from the order presented here, and from year to year.Recitation Section Required.

Prerequisites: concurrent registration in MATH V1101; for C1404: CHEM C1403 or W1403.

Topics include kinetic theory of gases, solutions, equilibria, oxidation-reduction, reactions, thermodynamics, chemical kinetics, the electronic structure of atoms, chemical bonding and its relationship to the geometries of molecules, periodic properties of the elements, transition metal complexes, and an introduction to organic chemistry and biochemistry.Recitation Section Required.

Corequisites: CHEM C1403 or W1403.

Laboratory Fee: $140. An introduction to basic techniques of modern experimental chemistry, including quantitative procedures and chemical analysis.

Prerequisites: CHEM C1403, C1604, or C3045 or the instructor's permission.

A one-hour weekly lecture, discussion, and critical analysis of topics that reflect problems in modern chemistry, with emphasis on current areas of active chemical research.

Prerequisites: CHEM C1604 or C3045.

Laboratory Fee: $140. An introduction to basic techniques and practices of modern experimental chemistry, including qualitative procedures and chemical analysis. This course differs from CHEM W1500 in its emphasis on instrumentation and methods.

Prerequisites: A grade of 5 on the Chemistry Advanced Placement exam and an acceptable grade on the Department placement exam.

Not open to students who have taken other courses in college-level chemistry. Premedical students may take CHEM C3045, C3046, and C3545 to meet the minimum requirements for admission to medical school. This course covers the same material as CHEM C3443-C3444, but is intended for students who have learned the principles of general chemistry in high school. The level of instruction is appropriate for those who have not had a college course in general chemistry. Students enrolled in CHEM C3045-C3046 are expected to enroll concurrently in CHEM W2507.Recitation Section Required.

Prerequisites: CHEM C1403 and C1404, or C1604, or C3045 and C3046; PHYS V1201-V1202 is acceptable, PHYS C1401-C1402 is recommended, or the equivalent; and MATH V1101-V1102 or V1207-V1208. Recommended corequisite: CHEM C3085-C3086.

Elementary but comprehensive treatment of the fundamental laws governing the behavior of individual atoms and molecules and collections of them. C3079: The thermodynamics of chemical systems at equilibrium and the chemical kinetics of nonequilibrium systems. C3080: The quantum mechanics of atoms and molecules, the quantum statistical mechanics of chemical systems, and the connection of statistical mechanics to thermodynamics. Recitation Section Required.

Prerequisites: CHEM C3085 is prerequisite for C3086.
Corequisites: CHEM C3079 for CHEM C3085 and C3080 for C3080.

Laboratory Fee: $125 per term. Techniques of experimental physical chemistry and instrumental analysis, including infrared and ultraviolet spectrophotometry, magnetic resonance, electroanalytical methods, calorimetry, reaction kinetics, hydrodynamic methods, and applications of digital computers to the analysis of experimental data.

Prerequisites: CHEM C1404 or W1404 or C1604, and W1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination.Recitation Section Required.

Prerequisites: CHEM C1404 or W1404 or C1604, and W1500.

The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Recitation Section Required.

Prerequisites: One year of biology and one year of organic chemistry. Recommended but not required: BIOC C3501.

Nucleic acid structure and enzymology. DNA replication, DNA repair, and transcription. RNA processing and translation. Biochemical approach to the study of gene expression and regulation with emphasis on the diseases caused when the basic processes are altered. Students may take BCHM G4026 in place of this course.

Recitation Section Required.

Prerequisites: CHEM W1500
Corequisites: CHEM C3443 or W3443.

Laboratory Fee: $125. Students planning to take a full year of laboratory should enroll in CHEM W3543 and W3546. Techniques of experimental organic chemistry, with emphasis on understanding fundamental principles underlying the experiments in methodology of solving laboratory problems involving organic molecules.

Prerequisites: CHEM W3543 or W3545.
Corequisites: CHEM C3444 or W3444.

Laboratory Fee: $125. A project laboratory with emphasis on complex synthesis and advanced techniques including qualitative organic analysis and instrumentation.

Prerequisites: Elementary organic chemistry.

Introduction to theory and practice of NMR spectroscopy. Instrumental aspects, basic NMR theory, NOE, and a survey of 2D methods are covered.

Prerequisites: Elementary physical and organic chemistry.

Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance, analysis of the conformation of proteins and nucleic acids; hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure.

Prerequisites: Elementary organic chemistry.

Recommended preparation: advanced organic chemistry. Various topics in bioactive molecules in the field centered on natural-products chemistry, metabolic transformations, and enzyme mechanisms. Biosysnthesis of natural products and some other bioorganic topics.

Prerequisites: Recommended for undergraduate students to have taken at least one semester of independent research.

This course offers undergraduate and graduate students an introduction to scientific writing and provides an opportunity for them to become more familiar with the skill and craft of communicating complex scientific research. This course will provide students with the basic grammatical, stylistic and practical skills required to write effective academic journal articles, theses, or research proposals. In addition, through an innovative partnership with Columbia University Libraries' Digital Science Center, students will learn how to apply these basic skills to their writing through the use of state-of-the-art software and online resources. Regular opportunities to write, peer edit and revise throughout the semester will allow students to put what they are learning into immediate practice. It is recommended that undergraduates have taken at least one semester of research for credit before taking this course. Undergraduates should plan to take this course after taking the required Core course University Writing.

Prerequisites: Physical chemistry sequence.

Molecular modeling has become an integral part of research in many areas of chemistry, and in industry in drug discovery and materials design. Many experimental papers in the literature are routinely complemented by molecular modeling calculations. Experimental scientists working in industry have a significant advantage if they know how to optimally use modeling software. The course would consist of a normal lecture part plus a lab session every week in which the students learn to use modeling software by working on projects.Lab Required.

Prerequisites: Chemistry G6222

Atomic and molecular quantum mechanics: electron correlation, configuration interaction, many-body perturbation theory, density functional methods.